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Histomorphological Study of Hemorrhage Related Changes In Simple Goiter

  

Farhat Rashid, Anwar Ul Haque

Ann. Pak. Inst. Med. Sci. 2012; 8(1): 58-62            

Objective: To determine the frequency of hemorrhage related histomorphological changes in simple goiter.
Study Design: Descriptive cross sectional study
Place and Duration: From September 2010 to February 2011, at the Department of Histopathology, Pakistan Institute of Medical Sciences.
Materials and Methods: 103 cases of simple goiter were studied for hemorrhage and its sequelae, using paraffin embedded Haematoxylin and Eosin stained sections.
Results: Hemorrhage (100% cases) was the most common finding followed by fibrosis (90.3% cases). Extravasated red blood cells and plasma in colloid, interfollicular stroma and blood vessel wall initiated an inflammatory response that led to fibrosis and subsequent dystrophic calcification. Fibrosis was not seen in diffuse hyperplastic and colloid goiter but was present in 97.9% cases of multinodular goiter.
Conclusion: Hemorrhage caused by venous congestion or minor external or internal trauma starts in diffuse hyperplastic and colloid goiter but fibrosis secondary to repeated hemorrhages is the main event in development of nodular goiter.
Key words: Goiter, Hemorrhage, Fibrosis.


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